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Harris became a pharmaceutical reporter at The Wall Street Journal, where his investigation of Bristol-Myers Squibb led to criminal charges against three top executives and the dismissal of its chief executive. He became the public health reporter for The New York Times, where his investigations led to the withdrawals of a multi-billion-dollar diabetes medicine and dozens of popular pediatric cough-and-cold drugs. His stories exposing secret payments from drug makers to prominent academics led to the passage of the Physician Payments Sunshine Act requiring pharmaceutical and medical device companies to report payments to physicians and teaching hospitals.

In 2012, Harris moved to New Delhi to become the Times’s South Asia correspondent. His series exposing India’s appalling levels of air pollution led to wholesale changes in law and lifestyles across the continent. His stories on India’s terrible sanitation and its effects on infant stunting led to a conclave at the United Nations General Assembly and the construction of more than 100 million toilets. His life was repeatedly threatened, and the Indian government revoked his press pass, a first for a Times correspondent.